Research Center Pharmaceutical Engineering GmbH

Founded in 2008, RCPE GmbH is an independent research center located in Graz (Austria) that performs cutting-edge research in the field of pharmaceutical process and product design.

Every day, we help our partners to develop and pioneer novel drugs and associated production routes, providing safe and more affordable therapies to patients. From early development to commercial production, we accompany our partners through all phases, utilizing our science-based, mechanistic understanding of products and processes.

As an international driver of pharmaceutical engineering science, RCPE offers tailored solutions to our partners, building upon our advanced capabilities in modeling and simulation, material science, PAT and process design. Moreover, RCPE features an international, multidisciplinary research team, unique laboratories and pilot plants suitable for even potent APIs.

RCPE is part of the following networks, clusters and initiatives:
human… RCPE Pilot Plant (ISO 9001, ISO 14001)

The pilot plant is extensively equipped, including a continuous extrusion system with hot-melt extruders, a wet extruder, a die-face cutter, a pelletizer, various feeding systems, a fully-instrumented laboratory tablet press, fluid-bed systems, a compaction simulator, granulators, nano-spray driers, capsule filling systems, filters, blenders, drug printers, crystallizers, coaters and much more.
The machines are used for process development, process understanding and the implementation of process-analytical tools for in-process monitoring, control and process optimization.

Regular maintenance and certification of the equipment and extensive training of the employees guarantee top research results and performance.

State-of-the-art pilot plant
Mixers, wet & dry granulators, compaction, coating, spray drying, continuous processing, etc.
Online NIR, Raman, UVVis, OCT, NIR GMP certified
500 m2 of state-of-the-art facilities
Pharma Standard Clean Rooms …. RCPE provides independent R&D in the field of pharmaceutical engineering, bridging the gap between science and industrial applications, ensuring pharmaceutical companies have the necessary predictive tools, methods and approaches to benefit from regulatory and industry-driven initiatives such as Quality by Design.

It is our intention to make our research capabilities and technological background available for companies on a service basis. Typical examples include measurements using our vast experimental and analytical capabilities, literature studies, feasibility studies, design studies, simulation work and other types of services.

Benefits

Diverse Research Activities
small preparatory studies up to extensive multi-year research programs are possible
Proven Scientific Excellence
multi-disciplinary teams, dedicated to customer needs
Maximum Output for Partners
defined & clear IPR strategies
Flexible Business Models
funded & non-funded cooperation scenarios to maximize cost efficiency…. Yes. service.

MATERIA NOVA is a research and development center based on advanced and disruptive technologies in the field of sustainable materials, multifunctional surfaces, materials for energy and biotechnology.

The 80 scientific experts from Materia Nova offer partnership with small, medium or large companies for research and/or development projects which are mainly carried out in the Materia Nova facilities and are validated at industrial scale either by its subsidiary companies (IONICS S.A. and NANO4 S.A.) or directly at customers site.

Materia Nova gives also technical assistance to companies such as in upscaling, feasibility testing, life cycle assessment, materials characterization, market research, state of the art, technology watch and targeted consulting. 
We perform measurement and analysis on materials and surfaces with a problem-solving perspective :

Morphology : microscopic analysis of surface morphology, microstructure analysis, Identification of contaminants (defects, size, shape, structure), Thickness layer measurement, Roughness measurement (Ra, Rt, Rq,…) using mechanical profilometer or Atomic Force Microscopy AFM), size measurement of particles or powders in solutions using laser particle size, Physico-chemical analysis and composition and Structural analysis

Physico-chemical analysis and composition :Characterization of the chemical composition of the materials (bulk / surface/interface: thin layers) and Position of the elements (or locating the elements) (SEM-EDS, XRF, XPS-ESCA, ToF-SIMS, TEM-EDS)

Structural analysis : X-Rays diffraction for the characterization of compounds and crystallized materials or powder such as metals, minerals, ceramics, pharmaceutical compounds, organometallic complex, …

For more…. Main fields of activities:

Upscaling on pilot or industrial equipment
Characterization, testing, materials analyses
Life Cycle Analysis (LCA)
R&D projects in the field of :

White biotechnology, (bio)polymers and (bio)composites
Sol-gel and wet coatings
Plasma technologies
Electrochemistry, corrosion
Organic electronics
Chemical sensors

 
. Yes. service.

The Chimie Balard Cirimat Carnot Institute provides companies with R&D support in Chemistry, Materials and Processes. We address environmental and societal concerns in the energy, health, cosmetics and transport industries. We offer innovative solutions to our partners, drawing upon our expertise in green chemistry and processes and in materials with enhanced properties. The comprehensive coverage of these areas by our research groups and the access to four state-of-the-art technological platforms allows us to meet any challenge.
Plateforme d'Analyse et Caractérisation (PAC) :

http://lmp.edu.umontpellier.fr/

SynBio3 :

http://www.polechimie-balard.fr/rub/317/presentation-synbio3.htm

ChemLab :

http://www.polechimie-balard.fr/rub/316/pilote-industriel-enscm.htm

Plateforme Nationale de Frittage Flash (PNF2) :

http://pnf2.cnrs.fr/

Plateforme Fabrication Additive :

http://www.cirimat.cnrs.fr/spip.php?article604
. Pluri-disciplinary research in key activity sectors:

- Energy: alternative fuels, fuel cells, hydrogen vector, electrochemical storage and conversion, structural materials for the nuclear power industry 

- Health and Cosmetics: drugs, vectors for drug delivery, biomaterials, pharmacological tools, medical devices 

- Transportation (aeronautics, space, rail, automobile): structural materials, coatings, components

- High-performance Materials: metals, alloys, nano-materials, ceramics, polymers, fabrication methods, durability

- Bio-sourced Chemicals and Materials
. Yes. service.

COMTES FHT a.s., a Czech privately owned research organization that pursues research and development (R&D) of advanced metals, non-metallic materials and methods and technologies for their processing. It also provides custom R&D services in the fields of computer modelling, software development, engineering design, manufacture of prototypes and specimens for testing, materials testing and elaborates expert reports on materials. In addition, the company contributes to educating young technical experts - students of Master's and Doctoral programs studying at partner universities in the Czech Republic (CZ) and abroad.

The research organization COMTES FHT was founded in 2000. COMTES FHT has successfully carried out and completed more than 40 R&D projects, including three projects of the EU Framework Programmes. The success of this research organization in applying its R&D results is evidenced by the authorship of dozens of proven technologies, thirteen patents (including two foreign ones) and more than twenty… Multifunctional Two-High/Four-High Rolling Mill - Custom-built rolling stand technology with many accessory equipment - heating furnaces and inductors, cooling tunnel and quenching bath for rapid cooling, shears, straightening bench, grinding machine – it enables more cost effective thermo-mechanical treatment of materials and controlled cooling. For material rolling under heat and cold conditions; verification of new rolling processes for materials.

Universal Forming Machine - Tailor-made machine, it offers a wide range of forming parameters (2,500 tons max. force), furnished with special equipment, e.g. manipulator, servo-hydraulic system allowing working ram stroke control. For free and die forging with; experimental verification of forging and press processes.

Vacuum Melting Furnace - : Equipment of capacity 10-50 l for production of new materials with re-alloying capability and heat analysis. The maximum mass of small steel melts for casting can reach up to 500 kg. Casting metallic materials;…. COMTES FHT a.s. since its establishment has been offering services in development of forming processes and heat treatment processes for metallic materials, materials research, technology transfer, innovation, testing and consultancy. The results are disseminated through scientific publications, utilized in projects of collaborative research which promise application potential, and in contract research. The research efforts at the centre are therefore of mixed nature. The core fields of activity of this organization comprise basic research, applied research and development using the organization’s own experimental and computing facilities. These include the newly-built physical simulation and numerical modelling laboratories, mechanical testing shops, metallographic, heat treating and forming, and engineering design laboratories. Examples of R&D areas are stated below:

R&D and optimisation of forming processes, and heat and thermomechanical treatment – through experiments conducted with the aid of a…. Yes. service.

The University of Warsaw Biological and Chemical Research Centre (CNBCh UW) serves as a centre for modern technologies by conducting scientific research that are strategically important for economic development of Poland. The CNBCh UW was established by the regulation of the Rector of the University of Warsaw on the 30th of May 2012 and it gathers the most talented young researchers, as well as experienced scientists from diverse disciplines who carry out innovative and interdisciplinary research at the interface of biology and chemistry. The mission of the center is to support the transfer of knowledge and technology into the economy, while strengthening collaboration between the University of Warsaw and the business sector.
Advanced research of the paramount scientific importance are carried out at the Centre that results enable further development of new technologies in the field of energetics, pharmaceutical analytics, medicines, biotechnology, protection of natural environment and cultural heritage… CNBCh UW includes the most up-to-date research equipment, among others:

X-ray Diffractometer System Agilent SuperNova, Atomic Force Microscoper Bruker dimension Icon, High Precision Mass Spectrometer Nu Instruments with Multi – Collector, Zeiss FIV-SEM Crossbeam Microscope, Transmission Electron Microscoper FEI Talos with EDS detector, Near Ambient Pressure X-Ray Photoelectron Spectromenter (NAP-XPS) CPEC, PET/SPECT/CT Carestream Albira imaging system for small animal research, Eckert and Ziegler Modular – Lab for radiopharmaceuticals synthesis, Thermo Scientific Orbitrap Fusion Mass Spectrometer, NMR Agilent 400MHz with autosampler, Activio-P11 Automated Peptide Synthesizer, Scribner Associated 850e Fuel Cell Test System,, UHPLC Agilent with Mass spectroscoopy detector and Orbitrap, Delta V Isotope Ratio Mass spectrometer, Potenstiostat/Galvanostat with impedance spectrometer 1260 A and adielectric module 1296 A Ametek 1287 A
. CNBCh UW cooperate and provide services in the following areas:

 - Complex analysis of chemical and biological substances regarding their structure, content and properties (including measurements with accordance to PN-EN ISO/EIC 17025:2005 ensuring the acceptance of results in areas that are regulated by law);

- Establishing modern, efficient processes of organic synthesis; 

- Environmental analyses and expertise, including i./a.: mycological expertise, monitoring of water quality and biological diversity of the environment, vegetation inventory, creating maps and plans of environmental systems;

- Simulation of protein molecular dynamics, designing new drugs and testing their bio-distribution and metabolism using isotopic and optic imaging techniques

- Designing and establishing new detectors, bio-detectors and electrode materials, and performing precise electrochemical measurements,

 - Establishing new materials, research on new energy sources and methods of its storage (accumulators and…. Yes. service.

VITO partners with industry to increase process efficiency and sustainability, and to evaluate the potential of alternative non-fossil resources in new value chains.

VITO’s industrial innovation targets the design of novel process concepts as well as improvement of existing ones. Core technology domains are:

Separation: membrane technology, extraction, electroseparation
Conversion: (electro)chemistry, (bio)catalysis
Integrated separation and conversion for process intensification.

VITO operates as an independent and neutral partner, at the interface between industry, academia and authorities and provides:

A multi-disciplinary international team of high level experts
A wide range of infrastructure & equipment
Fast & agile solutions
Access to a broad network (expertise & funding).

European networks:

Bio-Based Industries Consortium (BIC – www.biconsortium.eu)
PPP SPIRE - Sustainable Process Industry through Resource and Energy Efficiency (www.spire2030.eu)
… Equipment for:

Analytical characterization of biomass and processes
Biomass pretreatment and fractionation
Biocatalysis
(Gas) Fermentation
Green chemistry
(Bio)Process intensification
Downstream processing
Resource recovery

Technologies available at lab- and/or pilot scale include:

Low and high pressure membrane filtration
Organophilic and hydrophilic pervaporation
Membrane distillation
(Membrane-based) Capacitive deionization
(Membrane-based) (reactive) Extraction
Supercritical extraction
Fermentation

. VITO offers

Research from lab to pilot scale: conceptual design, process development and optimization, (integrated) process design, prototyping and testing, support up to full scale implementation
Techno-economic assessment of concepts and technologies
State-of-the-art infrastructure including facilities to work in a wide range of chemical conditions, and/or according to GMP regulations, as well as facilities to test your (GMO) organism
Objective advice, no strings with specific technology provider.

We have a multi-disciplinary team and advanced chemical analysis capabilities.

We guarantee strict non-disclosure.
. Yes. service.

The Leibniz Institute of Polymer Research Dresden (IPF) is one of the largest polymer research facilities in Germany. As an institute of the Leibniz Association, the IPF is committed to carrying out application-oriented fundamental research and receives its basic funding in equal parts from the federal and state governments.

The approach is holistic, covering synthesis and modification of polymer materials, their characterization and theoretical investigation, up to processing and testing. A special feature of the institute’s activities is the close cooperation of scientists and engineers and a broad range of modern instruments and methods are available including pilot plants allowing material and technology development under industry-relevant conditions.

The research focus is on materials problems and needs which can be approached by control of interface-related properties as well as interactions at interfaces and surfaces. A deep understanding of techniques and processes as well as of underlying… www.ipfdd.de
.
Fields of Research work

The institute's profile is determined by four strategic topics:

Functional nanostructured interfaces and polymer systems
Biology-inspired interface and material design
Polymer networks and supramolecular structures
Process-controlled structure formation in polymer materials

. Yes. service.

Doseo offers radiotherapy technology research and development resources unrivaled in Europe. Manufacturers, researchers, and clinicians can use our state-of-the art equipment for their own research and work with our expert scientists and technicians on joint R&D projects. 

One of Doseo’s missions is to open its doors to and build relationships with and between all radiotherapy stakeholders. Cooperation takes the form of partnerships between CEA LIST R&D scientists and technicians and manufacturing companies, academic institutions, and treatment centers.

These partnerships are designed to transfer new technology to businesses; speed the innovation process by leveraging diverse know-how from various disciplines; and take into account the viewpoints of end users, whose recommendations and approvals are vital to the process.

The French Alternative Energies and Atomic Energy Commission (CEA) contributes to industrial and economic growth through R&D partnerships that help businesses develop innovative… Doseo is home to a 1,000 sq. m technology platform used solely for R&D and training. The platform is also home to 600 sq. m of offices and meeting rooms so that our industrial, clinical, and academic partners, regulatory professionals, and visitors can take full advantage of the facilities.

Doseo boasts a very complete range of equipment representative of the installed base of radiotherapy and associated medical imaging equipment in use in France, with:

Medical-grade accelerators
Brachytherapy equipment
X-ray Computed Tomography scan (CT)
Irradiators
Measurement instruments
Calculation cluster
Conference and training rooms

. Doseo proposes four different types of services.

1. R&D partnerships

You can become an R&D partner by:

Signing a joint R&D agreement between your organization and CEA LIST
Taking part in a multi-partner research project under French and EU programs (French National Research Agency, French Single Ministerial Fund, EU Horizon 2020, etc.)

As a partner, you will work in synergy with Doseo’s research scientists. The Doseo platform, equipped with state-of-the-art technologies and managed by experts in radiotherapy and associated imaging technologies (metrology, simulation, instrumentation, and more), promises optimal R&D conditions.

2. Radiotherapy and imaging training programs

INSTN (France’s National Institute for Nuclear Science and Technology) works closely with its partners to provide radiotherapy and imaging training for professionals as well as for students. Training participants will have the exceptional opportunity to access the Doseo technology platform’s equipment and…. Yes. service.

The Institute of Natural Fibres and Medicinal Plants INF&MP (Intytut Włókien Naturalnych i Roślin Zielarskich, IWNiRZ) is an interdisciplinary research centre with international standing, involved in complex research on obtaining and processing of fibrous and herbal raw materials.
The main fields of IWNiRZ activities:

Biotechnology,
Breeding new cultivars of fibrous and medicinal plants, agronomy and preliminary processing,
Extraction and processing technologies of natural fibres and their modification for textile and non-textile applications,
Development of functional textiles including pro-healthy and medical products based on natural raw materials,
Agro-fine chemicals obtained from plants, nutrients and dietetic products,
New applications for oil cultivars of fibrous plants (dietetic and medicinal products),
Bio-fuels obtained from fibrous plants,
Development of renewable, biodegradable raw materials for industry,
Technologies of fire- and bio-retardants production,
Environmental…
Automatic Tensile Tester – STATIMAT ME - Determination of indices at static tension (elongation at break, tenacity, breaking force).
USTER AUTOSORTER III – Determination of yarn linear density (mass per unit length).
Martindale Abrasion and Pilling Tester – Determination of the abrasion resistance of fabrics and propensity to surface fuzzing and to pilling.
Air Permeability Tester III FX 3300 – Determination of permeability of fabrics to air.
Solarscreen Fabric Analyzer CARY 50 – Solar UV protective properties -method of test for apparel fabrics.
SGHP -8.2 (Sweating Guarde Hot Plate) - Determination of physiological properties. Measurement of thermal and water-vapour resistance under steady-state condition.
SEM S-3400N (Scanning Electron Microscope) – Evaluation of fibres surface as well as cross section, shape, fibre diameter, area of cross section, fibres damages and modification.
TGA FTIR – Set for quality and quantity identification on natural fibers.
Skin Surface Moisture Content –…. ·        Trainings in terms of material science of natural fibers and medicinal plants, agriculture methods of fibrous plants cultivation, technology of bast fibers extraction; training dedicated to SMS in textile, herbal and agriculture sector as well as handicrafts and artistic work based on natural fibers, natural dyeing and printing;

·        Prototyping – example:  prototype of clothing supporting skin diseases treatment;

·        Development of technologies of natural flax and hemp fibers extraction, modification, dyeing with natural dyestuff, nanocoating, functionalization, composites with the use of renewable resources, technology for obtaining cannabinoids from hemp with a low THC content, improvement of thermal and fire resistance;

·        Testing of fibers, semi-products and textile products, in terms of their properties, chemical composition, as well as test of textile influence on human body; flammability, microbiological tests, flax seed Lini semen (chemical composition and…. Yes. service.

VTT is a broad-scope contributor in international nuclear research. We provide contract services internationally - about 20% of commercial assignments are coming from abroad. VTT is independent and has a solid reputation as the leading Technical Support Organisation of the Finnish nuclear safety authority (STUK) for more than 30 years.

The VTT Centre for Nuclear Safety facility executes a wide range of research and testing activities on materials utilized in nuclear power plants and spent fuel final repository systems, particularly activities involving radioactive substances.A portfolio of standardized and accredited methods as well as sophisticated tools and techniques are available.Nuclear power plant operators and suppliers can have their materials tested for mechanical and chemical performance, and analysed for compositional and microstructural characteristics, both in the new, unused condition, as well as after operation in the plant environment or after accelerated aging or radiation exposures.

…
Hot cells for specimen fabrication, mechanical testing and microstructural characterization.  Capable of receiving components of up to 3.7 TBq Co-60 radioactivity in transport casks of up to 10 tonnes weight.
Zeiss Crossbeam 540 Analytical Scanning Electron Microscope (SEM) with EDAX Triade system for wavelength- and energy-dispersive x-ray spectroscopy and electron back-scatter detection (EDS, WDS and EBSD)
FEI TALOS F200X FEG Analytical Scanning/Transmission Electron Microscope with Gatan Enfinium SE/976 Electron energy loss spectroscopy (EELS).  Microscope has built-in 360° EDS via four energy dispersive spectrometers.
Cormet slow-strain rate testing autoclave and water circulation loop for up to 360°C and 220 bar operation, with simulated light water reactor primary circuit water chemistry environments and test durations from 1h to several months.
Radiochemistry laboratory for low activity specimens
Aerosol laboratory with several methods to generate gaseous and aerosol compounds
…. Services include expert assessments, particularly of radioactive and radioactively contaminated materials and components.Assessments include failure analyses of power plant components, accredited mechanical testing of radioactive materials, characterization and microanalysis studies of radioactive materials, radioactivity and radionuclide assessments, and customized R&D project and program planning and execution.
. Yes. service.